MOTS-c is classified as a mitochondrial-derived peptide (MDP), a newly identified class of signaling peptides encoded directly by mitochondrial DNA. Unlike conventional nuclear-encoded peptides, MOTS-c originates from the mitochondrial 12S rRNA gene region, previously not believed to encode functional peptides.

Research suggests that MOTS-c may act as a metabolic signaling regulator, particularly under conditions of cellular stress. In experimental models, it has been studied for its role in:

• Cellular energy homeostasis
• Metabolic stress adaptation
• Mitochondrial-to-nuclear signaling (retrograde signaling)
• Regulation of metabolic gene expression

Key Scientific Features

• Verified 16-amino-acid mitochondrial peptide sequence
• High-purity research-grade formulation (HPLC/MS validated)
• Lyophilized for long-term stability and storage efficiency
• Full Certificate of Analysis (COA) included per batch
• Produced under GMP-aligned, ISO-controlled laboratory conditions
• Suitable for mitochondrial signaling and metabolic research models

Research Applications (Non-Therapeutic)

Based on peer-reviewed scientific literature — not intended as medical claims.

MOTS-c is widely studied in preclinical research involving:

• AMPK pathway activation (energy-sensing signaling pathways)
• Glucose metabolism and uptake mechanisms (e.g., GLUT4-related studies)
• Skeletal muscle metabolic response models
• Mitochondrial stress adaptation and signaling pathways
• Inflammatory marker modulation in experimental systems (IL-6, TNF-α)
• Cellular energy balance and metabolic gene regulation

Scientific Evidence & References

Peer-reviewed research supporting MOTS-c biology and mitochondrial-derived peptide discovery:

• Original Discovery of MOTS-c (Cell Metabolism, 2015)
• NIH / PubMed Central Overview of MOTS-c Research
• Mitochondrial-Derived Peptides and Metabolic Regulation Review

These studies describe MOTS-c as a mitochondrial-encoded peptide involved in metabolic signaling and cellular energy regulation in experimental models.

Why Researchers Choose MOTS-c

• Matches the exact mitochondrial DNA–encoded sequence used in published studies
• High analytical purity with verified HPLC/MS testing
• Trusted in mitochondrial biology and metabolic research fields
• Consistent batch quality for reproducible laboratory results
• Supplied with full documentation and traceability

Handling & Stability

MOTS-c is supplied as a lyophilized peptide powder for enhanced stability. It should be stored in a refrigerated environment (2–8°C) and protected from light and moisture to maintain structural integrity during long-term storage.

Important Notice

For Research Use Only. Not for human or veterinary use.
This product is not a drug, supplement, cosmetic, or therapeutic agent. It is intended strictly for laboratory research and analytical applications.